An Iranian study of 504 men showed daily supplementation with an EPAX omega-3 triglyceride (TG) concentrate may support healthy PSA levels within a normal range.

The study, "­Effects of EPA, y-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomiszed, double-blind trial," published in the British Journal of Nutrition, showed how omega-3 fatty acids and coenzyme Q10 can alter serum prostate-specific antigen (PSA) levels in healthy men. Participants were randomly assigned to receive supplementation of one of three products ­ Epax 5500 TG omega-3, Nutri Q10, 2,400 mg of GLA ­ or a placebo for 12 weeks.

Use of the EPAX TG concentrate resulted in a 30 percent reduction in PSA levels, with a 33 percent drop with Nutri Q10. Supplements containing omega-6 (GLA) were linked to an increase in PSA levels. EPAX 5500 TG is a marine-derived omega-3 of 280 mg/g EPA and 180 mg/g DHA fatty acids and is a previous version of EPAX 6000 TG.

The study and abstract can be found at journals.cambridge.org.